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Additionally, copper-related DNA methylation alterations are linked to an elevated risk of acute coronary syndrome, suggesting an epigenetic role in the disease [197, 198]

The mechanism operates on multiple levels simultaneously

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Mar 2020;9(Suppl 2):S206-S214

The elevated antioxidant capacity driven by persistent NRF2 activation and enhanced glutathione (GSH) and thioredoxin (TRX) systems enables cancer cells to withstand endogenous oxidative stress and promotes metastatic behavior